Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day Outcomes From the Randomized Disrupt PAD III Trial

Randomized, controlled, multicenter trial at 45 centers in Austria, Germany, New Zealand, and the United States between February 2017 May 2020 (Shockwave Medical Peripheral Lithoplasty System Study for PAD, Santa Clara, California [Disrupt PAD III]). There were 306 patients with moderate or severe calcification a femoropopliteal artery who allocated randomly to vessel preparation intravascular lithotripsy (IVL) (n = 153) percutaneous transluminal angioplasty (PTA) followed by definitive treatment drug-coated balloon provisional stenting. Procedural success (66% vs 50%) percentage of lesions residual stenosis no more than 30% 52%) significantly greater IVL group, whereas flow-limiting dissections occurred frequently PTA group (1% 7%) after dilatation (5% 17%) stent placement 18%) group. is an effective strategy that facilitates endovascular calcified arteries.